Table 4.
Comparison of pre-operative flow metrics obtained by contrast and non-contrast MRI studies
| Contrast-based | Non-contrast-based | T-test | |||||
|---|---|---|---|---|---|---|---|
| M ± SD | R | N | M ± SD | R | N | ||
| Max perilesional flow | 23.7 ± 0.0 | 1, 15 | 26.4 ± 0.5 | 26.2–27.4 | 2, 117 | t = 60.0, p < 0.001 | |
| Max perilesional relative flow - white matter reference | 1.6 ± 0.4 | 1.1–2.0 | 4, 89 | 1.1 ± 0.0 | 1, 24 | t = 10.1, p < 0.001 | |
| Mean TBF* | 42.6 ± 25.0 | 4.2–63.9 | 4, 70 | 79.1 ± 41.5 | 12.1–136.5 | 11, 223 | t = 9.0, p < 0.001 |
| Max TBF | 151.6 ± 0.0 | 1, 15 | 130.4 ± 52.3 | 46.9–250.0 | 11, 270 | t = 6.7, p < 0.001 | |
| Mean rTBF - all reference ROIs* | 2.9 ± 2.0 | 1.5–7.9 | 3, 192 | 3.1 ± 1.9 | 0.9–5.7 | 6, 144 | t = 0.59, p = 0.56 |
| Mean rTBF - white matter reference* | 2.9 ± 2.0 | 1.5–7.9 | 3, 192 | 4.1 ± 1.5 | 1.3–5.7 | 3, 92 | t = 5.6, p < 0.001 |
| Max rTBF - all reference ROIs* | 4.0 ± 1.8 | 1.0–7.3 | 20, 355 | 3.5 ± 2.9 | 1.0–9.5 | 17, 330 | t = 3.0, p = 0.003 |
| Max rTBF - mixed* | 3.8 ± 1.7 | 1.7–5.9 | 5, 109 | 5.3 ± 3.0 | 1.3–9.5 | 6, 169 | t = 5.1, p < 0.001 |
| Max rTBF - white matter reference* | 4.1 ± 1.8 | 1.0–7.3 | 15, 246 | 1.3 ± 0.2 | 1.1–1.6 | 4, 59 | t = 24.2, p < 0.001 |
| Max rTBF - grey matter reference* | 1.2 ± 0.5 | 0.6–1.7 | 3, 46 | 1.8 ± 0.5 | 1.0–2.7 | 6, 96 | t = 6.6, p < 0.001 |
ANOVA, One way analysis of variance; CBF, Cerebral blood flow; M ± SD, Mean±standard deviation; N, Number of studies followed by number of patients between studies; N/A, Current statistical test could not be performed; R, Range; ROI, Region of interest; TBF, Tumoral blood flow; rTBF, Relative tumoral blood flow.
This table shows blood flow metrics that were comparable between contrast and non-contrast based MRI studies. Where n > 30 for both imaging types (*), there was a trend for non-contrast based methods to produce higher flow results. All absolute flow metrics are in ml/100 g/min and all relative flow values are unitless.