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. 2022 Jul 13;13:911381. doi: 10.3389/fimmu.2022.911381

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Copyright © 2022 Wang, Jia, Celi, Zhuo, Ding, Zeng, Bai, Xu, Yin, Lv and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dietary resveratrol supplementation alleviated the oxidative stress (by tBHP) induced depression in follicle counts and cell apoptosis (Exp. 1). (A) Ovarian histology of layers after 24 days of treatment. (B) Follicle numbers at each developmental stage (PMF= primordial follicle; PF = primary follicle; PHF = prehierarchical follicle; AF = atretic follicle). (C) TUNEL analysis of cell apoptosis in the ovary. (D) The immunofluorescence results of TUNEL with the green color representing the positive cells. Data are plot individual values (n = 10). CON, control; OS, oxidative stress (injection of 800 μmol/kg BW of tBHP); OSR, CON + 600 mg/kg resveratrol. Statistical significance was evaluated by Tukey’s Test, p < 0.05.