Table 2.
Mean ± standard deviation of the median values obtained from the tumour volumes for responders and non-responders
| MRI parameters | Responders (n = 6) | Non-responders (n = 4) | ||||
|---|---|---|---|---|---|---|
| Visit 1 | Visit 2 | Post-RT visit | Visit 1 | Visit 2 | Post-RT visit | |
| ADC (x10-5 mm2/s) | 229.3 ± 47.9 | 251.8 ± 24.3 | 238.6 ± 27.7 | 227.2 ± 27.7 | 246.2 ± 29.8 | 193.7 ± 51.8 |
| T2a (ms) | 163.6 ± 75.7 | 145.9 ± 86.4 | 58.0 ± 25.0 | 64.2 ± 54.8 | 63.7 ± 47.0 | 33.8 ± 17.9 |
| (Gd) (a10–3 mmol ml−1) | 0.5 ± 0.2a | 0.42 ± 0.22 | 0.16 ± 0.13 | 0.09 ± 0.05a | 0.14 ± 0.08 | 0.10 ± 0.03 |
| IAUGC (mmol*s) | 7.5 ± 3.0a | 7.0 ± 5.0 | 3.7 ± 2.1 | 1.8 ± 1.1a | 3.1 ± 0.9 | 3.3 ± 1.1 |
| Ktrans (min-1) (adjusted to EF) | 0.07 ± 0.02a | 0.06 ± 0.04 | 0.04 ± 0.03 | 0.02 ± 0.01a | 0.03 ± 0.01 | 0.03 ± 0.01 |
| Volume (cc) | 54.3 ± 40.8 | 43.3 ± 33.2 | 23.8 ± 19.7 | 64.7 ± 58.7 | 65.0 ± 60.0 | 40.5 ± 40.0 |
| RECIST 1.1 response classificationb | Partial response (n = 4) Stable disease (n = 2) |
Partial response (n = 1) Stable disease (n = 3) |
||||
ADC, apparent diffusion coefficient; RT, radiotherapy.
Response classification according to RECIST 1.1 criteria. Number of patients considered for the calculations are clearly stated in the legend of Figure 3.
a
Denotes significant differences between responders and non-responders.
b
Please see Supplementary Table 1 for the RECIST 1.1 classification of all 10 patients separately.