TABLE 2.

List of relevant orthogroups

OG	Viruses	Homology results
alphaOG16	Seven bat viruses	Family of viral and host proteins containing Ig‐like domains (e.g., HCMV RL11 and adenovirus protein E3)
alphaOG20	All rodent CoVs (luchacoviruses)	Spike protein of alphaCoVs (SADS‐CoV and HKU2)
alphaOG63	Two rodent viruses	C‐type lectin domain
alphaOG86	FIPV and TGEV	Phosphoribosylamine–glycine ligase domain of bacterial and eukaryotic organisms
betaOG09	Most merbecoviruses; includes MERS‐CoV ORF4a/NS4a	RNA binding proteins, either from viruses (e.g., nonstructural protein 3 of Rotavirus C, Pernambuco mycovirus 1, Thika virus, NSP1 from Porcine rotavirus) or from cellular organisms (e.g., rat dsRNA‐specific editase 1, human interferon‐inducible double stranded RNA‐dependent protein kinase activator A, human TAR RNA‐binding protein 2)
betaOG13	All embecoviruses	Influenza virus and torovirus haemagglutinin‐esterase
betaOG36	Subset of merbecoviruses hosted by hedgehogs	Several viral and cellular proteins carrying Ig‐like domains. Most viral proteins with high similarity are encoded by human herpesviruses
betaOG56	Two bat nobecoviruses	Rotavirus ns1‐1 proteins
betaOG78	Only one hibecovirus	SARS‐CoV‐2 spike protein
gammaOG15	Three cegacoviruses	Capsid protein (VP90) of mamastoviruses and human/porcine artroviruses
gammaOG18	Three cegacoviruses	Uridine kinases from many different cellular organisms
deltaOG12	Six Buldecoviruses	ns1‐1 product of Rotavirus B