Table 2.
Monocyte and Macrophage Fate Mapping Toolbox
| Promoter | Model | Target cell | Reference |
|---|---|---|---|
| Cx3cr1 | cre | Monocytes/macrophages | (Yona et al., 2013) |
| creER | Monocytes/macrophages | (Yona et al., 2013) | |
| GFP/+ | Monocytes/macrophages | (Bain et al., 2014; Ginhoux et al., 2010; Jung et al., 2000) | |
| Ccr2 | cre | Monocytes/macrophages /DCs | (Heung & Hohl, 2019) |
| creER | Monocytes/macrophages /DCs | (Amorim et al., 2022; Chen et al., 2020; Croxford et al., 2015; Dick et al., 2022; Gallerand et al., 2021; Xu et al., 2020) | |
| GFP/+ | Monocytes/macrophages /DCs | (Satpathy et al., 2013) | |
| RFP/+ | Monocytes/macrophages /DCs | (Saederup et al., 2010) | |
| Ms4a3 | cre | GMP/monocytes | (Amorim et al., 2022; Liu et al., 2019) |
| creER | GMP/monocytes | ||
| TdTomato | GMP/monocytes | ||
| Csf1r | cre | Monocytes/macrophages | (Deng et al., 2010; Schulz et al., 2012) |
| merCREmer | Monocytes/macrophages | (Epelman et al., 2014; Gomez Perdiguero et al., 2015; Qian et al., 2011; Schulz et al., 2012) | |
| EGFP (MacGreen) | Monocytes/macrophages | (Sasmono et al., 2003) | |
| Flt3 | cre | HSC‐derived cells | (Boyer, Schroeder, Smith‐Berdan, & Forsberg, 2011; Schulz et al., 2012) |
| Runx1 | merCREmer | HSC and embryonic progenitor cells | (Hoeffel et al., 2015; Hoeffel et al., 2012; Samokhvalov et al., 2007) |
| LysM | GFP/+ | Monocytes/neutrophil/macrophages | (Faust, Varas, Kelly, Heck, & Graf, 2000) |
| cre | Monocytes/neutrophil/macrophages | (Clausen, Burkhardt, Reith, Renkawitz, & Förster, 1999) | |
| Gata6 | (roxstoprox) icreER | Large peritoneal/serous cavity macrophages | (Jin et al., 2021) |
| F4/80 | cre | Macrophages | (Schaller et al., 2002) |
| cKIT | cre | Hematopoietic progenitor cells | (Hatzistergos et al., 2015) |
| creER | Hematopoietic progenitor cells | (Stremmel et al., 2018; Van Berlo et al., 2014) | |
| Lyve1 | cre | Lyve1+ macrophages | (Pham et al., 2010; Zhang et al., 2021) |
| creER | Lyve1+ macrophages | (Connor, Kelley, & Tempero, 2016) |
Common mouse models that are useful for applying macrophage fate‐mapping approaches to different macrophage subsets and tissues. Primary immune cell types labeled with these models are listed under “Target Cell”.
GMP (granulocyte‐monocyte progenitor), HSC (hematopoietic stem cell), DC (dendritic cells).