Table 2.
Table showing HEPA 1-6 tumour infiltrating immune cells after completion of ICI treatment. Data are shown as mean%of cells ± S.D. and are separated into control, treatment responders (TR), and treatment nonresponders (TNR) and are representative of n = 5 − 10 mice/group, ∗P < 0.05; ∗∗P < 0.01, comparing TR to TNR.
| Immune cell subsets associated with HEPA 1-6 tumours | ||||
|---|---|---|---|---|
| CD3+ % of CD45+ | CD4+ % of CD3+ | CD4+ Treg % of CD4+ | GZB+ NK+ % of NK+ | |
| Control | 30.10 ± 1.17 | 19.85 ± 2.50 | 5.17 ± 1.27 | 8.39 ± 1.90 |
| TR αPD1 | 40.80 ± 6.43∗ | 18.18 ± 1.81 | 2.18 ± 0.61∗ | 11.92 ± 1.22∗ |
| αCTLA4 | 43.95 ± 3.76∗ | 31.78 ± 4.62∗ | 2.71 ± 0.45∗ | 15.50 ± 2.81∗ |
| αPD1 + αCTLA4 | 41.56 ± 5.42∗ | 33.35 ± 3.01∗ | 2.11 ± 0.28∗ | 16.08 ± 1.04∗∗ |
| TNR | 30.98 ± 1.54 | 23.68 ± 2.16 | 5.02 ± 1.47 | 8.74 ± 1.02 |