TABLE 2.
Endogenously produced polypeptide hormones with regulatory function show a very rapid clearance (t 1/2) from blood
| Polypeptide hormones | Secreted by | Amino acids | t 1/2, min |
|---|---|---|---|
| Insulin | Pancreas | 51 | 4–6 |
| Glucagon | Pancreas | 29 | 3–5 |
| Glp‐1 | Ileum L cells | 30 | 1–3 |
| GIP | Duodenum, K cells | 42 | 2–5 |
| PYY | Ileum, L cells | 36 | 3–4 |
| CCK | Duodenum, L cells | 8–58 | 2–3 |
| VIP | Intestinal immune cells and neurons | 28 | 1–2 |
Note: Abbreviations: GLP1, glucagon‐like peptide 1; GIP, gastric inhibitory polypeptide; PYY, peptide‐YY; CCK, cholecystokinine; VIP, vasoactive intestinal peptide.