Table 1.

Haemodynamic data

	Baseline	Volume	Dobutamine	AMI
Number of animals (n)	18	6	8	6
Heart rate (beats min–1)	72 ± 3	63 ± 4*	112 ± 3*	74 ± 4
Stroke volume (mL)	37 ± 2	36 ± 3	28 ± 3*	28 ± 3*
Cardiac index (L min−1 m−2)	2.1 ± 0.2	1.8 ± 0.2	2.5 ± 0.2	1.8 ± 0.2
Pulmonary haemodynamics
Pulmonary systolic arterial pressure (mmHg)	34 ± 2	39 ± 2	52 ± 2*	36 ± 2
Pulmonary diastolic arterial pressure (mmHg)	16 ± 1	20 ± 1*	22 ± 1*	17 ± 1
Pulmonary mean pressure (mmHg)	25 ± 1	29 ± 1*	34 ± 1*	27 ± 2
Left atrial mean pressure (mmHg)	8 ± 1	14 ± 1*	8 ± 1	8 ± 1
Pulmonary vascular resistance (dyn s cm−5)	667 ± 115	671 ± 138	782 ± 131	778 ± 140
Pulmonary arterial elastance (mmHg mL−1)	0.88 ± 0.14	0.99 ± 0.17	1.53 ± 0.16*	1.04 ± 0.17
Pulmonary vascular compliance (mL mmHg−1)	2.2 ± 0.2	2.0 ± 0.2	1.1 ± 0.2*	1.6 ± 0.2*
Total hydraulic power (mW)	207 ± 29	195 ± 45	553 ± 40*	182 ± 46
Steady hydraulic power (mW)	176 ± 24	176 ± 37	453 ± 34*	153 ± 38
Pulsatile hydraulic power (mW)	31 ± 6	20 ± 9	100 ± 8*	28 ± 9
Pulmonary pulsatile power fraction	0.16 ± 0.01	0.13 ± 0.01	0.18 ± 0.01	0.16 ± 0.01
Left ventricle
LV systolic pressure (mmHg)	81 ± 3	88 ± 5	111 ± 4*	76 ± 4
LV Tau (ms)	65 ± 3	70 ± 5	40 ± 4*	64 ± 4
LV end diastolic pressure (mmHg)	7 ± 1	13 ± 2*	7 ± 1	7 ± 1
LV End‐diastolic volume (mL)	48 ± 2	55 ± 4	39 ± 3	52 ± 4
LV End‐systolic volume (mL)	15 ± 1	18 ± 2	13 ± 2	23 ± 2*
LV Ejection fraction (%)	68 ± 2	68 ± 4	67 ± 3	55 ± 3*
LV dP/dt max (mmHg s−1)	1622 ± 183	2007 ± 367	4843 ± 249*	1434 ± 283
Right ventricle
RV Tau (ms)	60 ± 3	66 ± 5	37 ± 4*	69 ± 4*
RV end diastolic pressure (mmHg)	5 ± 0	11 ± 1*	4 ± 1*	6 ± 1
RV End‐diastolic volume (mL)	43 ± 3	71 ± 4*	35 ± 3*	51 ± 3*
RV End‐systolic volume (mL)	23 ± 2	42 ± 2*	18 ± 2*	31 ± 2*
RV Ejection fraction (%)	46 ± 2	42 ± 3	48 ± 2	40 ± 2*
RV dP/dt max (mmHg s−1)	582 ± 48	702 ± 115	1360 ± 71*	605 ± 78

Values show least squares mean ± SE. dP/dt _max, peak of the temporal derivative of pressure, Tau, time‐constant of ventricular relaxation.

^* P < 0.05 vs. baseline