Table 2.
Characteristics of study population by HOMA‐IR quartiles of NT
| NT with NGT group (n=11949) | NT with pre‐DM group (n=6205) | NT with DM group (n=2273) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | LnHOMA‐IR(1) | LnHOMA‐IR(2) | LnHOMA‐IR(3) | LnHOMA‐IR(4) | P value | LnHOMA‐IR(1) | LnHOMA‐IR(2) | LnHOMA‐IR(3) | LnHOMA‐IR(4) | P value | LnHOMA‐IR(1) | LnHOMA‐IR(2) | LnHOMA‐IR(3) | LnHOMA‐IR(4) | P value |
| n=4883 | n=3825 | n=2295 | n=946 | n=1305 | n=1565 | n=1772 | n=1563 | n=208 | n=338 | n=564 | n=1163 | ||||
| Age，years | 54.60±8.17 | 54.33±8.13 | 53.89±7.83 | 53.98±7.96 | 0.002 | 57.96±9.76 | 56.88±9.02 | 56.53±8.59 | 56.07±8.37 | <0.001 | 60.22±8.69 | 59.17±8.97 | 59.22±8.87 | 58.43±8.92 | 0.03 |
| BMI，Kg/m2 | 22.10±3.07 | 23.55±2.96 | 24.69±3.23 | 25.95±3.40 | <0.001 | 22.12±3.12 | 23.77±3.26 | 24.79±3.10 | 26.42±3.28 | <0.001 | 22.19±2.99 | 23.67±3.26 | 24.50±3.85 | 25.94±3.47 | <0.001 |
| Wc‐hc | 0.86±0.07 | 0.87±0.07 | 0.88±0.08 | 0.89±0.07 | <0.001 | 0.87±0.07 | 0.88±0.08 | 0.89±0.06 | 0.90±0.07 | <0.001 | 0.88±0.06 | 0.89±0.06 | 0.90±0.07 | 0.91±0.06 | <0.001 |
| AST‐ALT | 1.61±0.52 | 1.50±0.50 | 1.38±0.47 | 1.26±0.46 | <0.001 | 1.68±0.88 | 1.50±0.53 | 1.39±0.50 | 1.27±0.47 | <0.001 | 1.59±0.82 | 1.39±0.55 | 1.33±0.52 | 1.19±0.41 | <0.001 |
| TG，mmol/L | 1.12±0.74 | 1.33±0.84 | 1.55±1.04 | 1.91±1.27 | <0.001 | 1.24±0.82 | 1.58±1.06 | 1.87±1.38 | 2.06±1.36 | <0.001 | 1.43±1.36 | 1.57±1.33 | 1.78±1.17 | 2.21±1.78 | <0.001 |
| CHOL，mmol/L | 4.77±1.15 | 4.91±1.15 | 4.97±1.19 | 5.05±1.22 | <0.001 | 4.73±1.21 | 4.92±1.19 | 4.95±1.21 | 5.04±1.24 | <0.001 | 4.69±1.10 | 4.81±1.12 | 4.87±1.22 | 5.02±1.23 | <0.001 |
| LDL，mmol/L | 2.76±0.88 | 2.90±0.88 | 2.96±0.94 | 3.02±0.95 | <0.001 | 2.72±0.89 | 2.89±0.90 | 2.88±0.90 | 2.98±0.97 | <0.001 | 2.69±0.78 | 2.79±0.82 | 2.85±0.95 | 2.94±0.95 | <0.001 |
| HDL，mmol/L | 1.41±0.37 | 1.35±0.36 | 1.29±0.33 | 1.22±0.34 | <0.001 | 1.36±0.39 | 1.28±0.33 | 1.23±0.33 | 1.19±0.31 | <0.001 | 1.29±0.34 | 1.26±0.32 | 1.22±0.35 | 1.17±0.29 | <0.001 |
| GFR(mL/min*1.73m²) | 99.37±21.90 | 97.40±21.34 | 97.25±20.94 | 96.46±21.59 | <0.001 | 101.28±23.58 | 98.29±20.77 | 96.43±20.28 | 95.37±20.40 | <0.001 | 98.46±24.73 | 98.20±19.79 | 96.30±22.51 | 94.23±22.01 | 0.004 |
| Ln(UACR/Median) | ‐0.14±1.00 | ‐0.13±0.99 | ‐0.17±1.04 | ‐0.08±1.05 | 0.07 | ‐0.13±0.96 | ‐0.09±0.89 | ‐0.05±0.88 | ‐0.01±0.94 | <0.001 | 0.04±0.93 | 0.19±0.95 | 0.13±1.13 | 0.31±1.11 | <0.001 |
| Sex(male) | 31.4 (1531) | 24.2(927) | 23.4 (580) | 23.3 (234) | <0.001 | 46.2(603) | 30.0(469) | 26.8(475) | 25.8(404) | <0.001 | 53.8(112) | 51.5(174) | 44.1(249) | 41.1(478) | <0.001 |
| Smoking habits，% | <0.001 | <0.001 | 0.0386 | ||||||||||||
| Never smoker | 81.8(3947) | 86.4(3289) | 88.2(2167) | 87.6(872) | 77.8(1008) | 85.4(1327) | 88.2(1544) | 87.3(1351) | 76.3(158) | 76.6(256) | 79.9(448) | 79.4(914) | |||
| Sometimes smoker | 2.2(105) | 2.0(78) | 2.9(72) | 2.4(24) | 3.7(48) | 3.0(47) | 2.7(47) | 3.2(50) | 2.9(6) | 4.8(16) | 4.6(26) | 3.3(38) | |||
| Regular smoker | 16.1(775) | 11.5(438) | 8.9(219) | 10.0(100) | 18.5(240) | 11.5(179) | 9.1(160) | 9.5(147) | 20.8(43) | 18.6(62) | 15.5(87) | 17.3(199) | |||
| Drinking habits，% | <0.001 | <0.001 | 0.483 | ||||||||||||
| Never drinker | 70.5(3414) | 73.3(2786) | 75.6(1853) | 75.8(755) | 66.4(860) | 72.5(1126) | 76.4(1343) | 76.3(1185) | 70.7(145) | 71.9(241) | 75.2(422) | 74.6(862) | |||
| Sometimes drinker | 22.6(1093) | 22.0(834) | 20.3(497) | 19.6(195) | 22.9(297) | 21.2(329) | 19.8(348) | 18.9(294) | 20.5(42) | 22.1(74) | 18.4(103) | 17.9(207) | |||
| Regular drinker | 6.9(334) | 4.7(179) | 4.2(102) | 4.6(46) | 10.7(138) | 6.4(99) | 3.9(68) | 4.8(74) | 8.8(18) | 6.0(20) | 6.4(36) | 7.5(87) | |||
Note: Data were mean ± SD or median (IQR) for skewed variables or numbers (proportions) for categorical variables.
AST‐ALT, aspartate aminotransferase to alanine aminotransferase rate; BMI, body mass index; CHOL, cholesterol; DBP, diastolic blood pressure; GFR, glomerular filtration rate; HDL‐C, high density lipoprotein cholesterol; HOMA‐IR, homeostasis model assessment of insulin resistance; hypertension (HT, SBP ≥140 mmHg or DBP ≥90 mmHg); IQR, interquartile range; LDL‐C, low density lipoprotein cholesterol; SBP, systolic blood pressure; TG, triglycerides; UACR, urinary albumin‐creatinine ratio; Wc‐hc，waist‐to‐height ratio.