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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Adv Redox Res. 2022 Jun 9;5:100040. doi: 10.1016/j.arres.2022.100040

Fig. 3.

Fig. 3.

Increased levels of ROS in situ in CF pancreas can be inhibited with SOD mimetic compounds. Pig pancreata were harvested and cryo-sectioned as in Fig. 2, but some specimens had 500 nM GC4401, an SOD mimetic, or GC4404, an inactive analogue, included in the reaction during the DHE staining. Cells were then analyzed as in Fig. 2. GC4401 was able to inhibit greater than 75% of the signal from DHE oxidation under these conditions, supporting the hypothesis that superoxide levels are increased in CF pancreas.