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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Adv Redox Res. 2022 Jun 9;5:100040. doi: 10.1016/j.arres.2022.100040

Fig. 8.

Fig. 8.

Apocynin does not reverse insulin secretory defects in perifused CF islets. Glucose stimulated insulin secretion was impaired in CF compared to non-CF cultured neonatal islets (A). 24 h culture with apocynin (apo) failed to impact insulin secretion in CF islets (B) or non-CF islets (C). Likewise, glucose stimulated insulin secretion as measured as incremental area under the curve (iAUC) was impaired in CF versus non-CF animals, but was not impacted by apocynin (D). Values for all graphs show the mean +/− SEM from independent animals. * p<0.05 for indicated time points (A) or iAUC (D), as assessed by 2-way ANOVA.