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. 2021 Feb 2;178(5):1001–1017. doi: 10.1111/bph.15349

TABLE 3.

Effects of ions, pH and receptor antagonists on the NMDA auto and heteroreceptors

Mg2+ ions Dizocilpine D‐AP5CGS19755 7‐Cl‐Kyna Zn2+ ions (RS)‐CPP Ifenprodil pH 6.0 pH 8.0
NMDA heteroreceptors
Dopamine (striatum) ↓ ↓ ↓ ↓. n.e. n.d. ↓ n.e. n.e.
Dopamine (NAc) ↓ ↓ ↓ ↓. n.e. n.e. ↓ n.e. n.e.
Noradrenaline ↓ ↓ ↓ ↓. n.e. n.d. ↓ ↓ ↑
Acetylcholine n.e. ↓ n.d. n.d. n.d. n.d. n.d. n.d. n.d.
GABA ↓ ↓ n.d. n.d. n.d. n.d. n.d. n.d. n.d.
CCK‐LI/SRIF‐LI n.e. ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓
NMDA autoreceptors
Hippocampus n.e. ↓ ↓ ↓ ↓ n.d. ↓ ↓ ↑
Nucleus accumbens ↓ ↓ n.d. ↓ n.d. ↓ n.e. n.d. n.d.
Cortex n.e. ↓ n.d. n.d. n.d. n.d. n.d. n.d.
Spinal cord ↓ ↓ n.d. n.d. ↓ n.d. ↓ ↓ n.d.

Note. ↓, decreased transmitter release; n.d., not determined; n.e., no effect.