Table 2a.

League table for response rates associated with studied pharmacological agents. For interpretation, a number larger than zero favors the column-defining treatment of a cell. Values are RR with associated 95% confidence intervals.

Aripiprazole

1.01 (0.72; 1.41)

Brexpiprazole

1.37 (1.08; 1.74)

1.36 (0.94; 1.97)

Bupropion

1.44 (1.11; 1.87)

1.43 (0.98; 2.08)

1.05 (0.84; 1.33)

Buspirone

1.31 (1.05; 1.64)

1.30 (0.92; 1.84)

0.96 (0.73; 1.26)

0.91 (0.69; 1.21)

Cariprazine

1.29 (0.91; 1.84)

1.28 (0.82; 1.99)

0.94 (0.64; 1.39)

0.90 (0.60; 1.33)

0.98 (0.68; 1.42)

Lamotrigine

1.33 (1.08; 1.63)

1.32 (0.94; 1.84)

0.97 (0.75; 1.26)

0.92 (0.71; 1.20)

1.01 (0.81; 1.26)

1.03 (0.72; 1.47)

Lisdexamfetamine

1.26 (0.97; 1.64)

1.25 (0.86; 1.81)

0.92 (0.68; 1.25)

0.87 (0.64; 1.19)

0.96 (0.73; 1.27)

0.97 (0.67; 1.41)

0.95 (0.73; 1.23)

Lithium

1.29 (0.88; 1.90)

1.28 (0.81; 2.04)

0.95 (0.62; 1.43)

0.90 (0.59; 1.36)

0.99 (0.67; 1.46)

1.00 (0.62; 1.62)

0.97 (0.67; 1.42)

1.03 (0.68; 1.56)

Methylphenidate

1.22 (0.90; 1.65)

1.21 (0.81; 1.81)

0.89 (0.63; 1.25)

0.85 (0.60; 1.20)

0.93 (0.68; 1.27)

0.94 (0.62; 1.43)

0.92 (0.68; 1.24)

0.97 (0.69; 1.37)

0.94 (0.61; 1.47)

Mirtazapine

1.25 (1.00; 1.56)

1.24 (0.88; 1.75)

0.91 (0.70; 1.20)

0.87 (0.66; 1.14)

0.95 (0.75; 1.20)

0.97 (0.67; 1.39)

0.94 (0.76; 1.17)

0.99 (0.75; 1.30)

0.96 (0.65; 1.42)

1.02 (0.75; 1.40)

Modafinil

0.77 (0.38; 1.56)

0.76 (0.36; 1.62)

0.56 (0.27; 1.16)

0.53 (0.26; 1.11)

0.58 (0.29; 1.20)

0.59 (0.28; 1.28)

0.58 (0.28; 1.17)

0.61 (0.29; 1.26)

0.59 (0.27; 1.29)

0.63 (0.30; 1.32)

0.61 (0.30; 1.26)

Nortriptyline

1.28 (1.00; 1.65)

1.27 (0.88; 1.83)

0.94 (0.70; 1.26)

0.89 (0.66; 1.21)

0.98 (0.75; 1.28)

0.99 (0.68; 1.46)

0.97 (0.75; 1.24)

1.02 (0.76; 1.37)

0.99 (0.66; 1.49)

1.05 (0.75; 1.47)

1.03 (0.79; 1.34)

1.67 (0.81; 3.45)

Olanzapine

1.17 (0.71; 1.92)

1.16 (0.66; 2.03)

0.85 (0.51; 1.44)

0.81 (0.48; 1.37)

0.89 (0.54; 1.47)

0.90 (0.51; 1.61)

0.88 (0.53; 1.44)

0.93 (0.55; 1.57)

0.90 (0.50; 1.63)

0.96 (0.56; 1.65)

0.94 (0.57; 1.55)

1.52 (0.66; 3.53)

0.91 (0.54; 1.53)

Pramipexole

1.18 (0.95; 1.46)

1.17 (0.83; 1.64)

0.86 (0.66; 1.12)

0.82 (0.62; 1.07)

0.90 (0.71; 1.13)

0.91 (0.64; 1.29)

0.88 (0.72; 1.09)

0.93 (0.77; 1.14)

0.91 (0.62; 1.34)

0.96 (0.71; 1.31)

0.94 (0.75; 1.18)

1.53 (0.75; 3.12)

0.92 (0.71; 1.18)

1.01 (0.61; 1.66)

Quetiapine

1.29 (0.96; 1.74)

1.28 (0.86; 1.91)

0.94 (0.69; 1.29)

0.90 (0.67; 1.20)

0.98 (0.72; 1.34)

1.00 (0.66; 1.51)

0.97 (0.72; 1.31)

1.03 (0.73; 1.44)

1.00 (0.64; 1.55)

1.06 (0.73; 1.53)

1.03 (0.76; 1.40)

1.68 (0.80; 3.53)

1.01 (0.72; 1.40)

1.11 (0.64; 1.90)

1.10 (0.81; 1.48)

Risperidone

0.83 (0.50; 1.39)

0.82 (0.46; 1.47)

0.61 (0.36; 1.03)

0.58 (0.34; 0.98)

0.63 (0.38; 1.07)

0.64 (0.36; 1.15)

0.62 (0.37; 1.05)

0.66 (0.41; 1.06)

0.64 (0.35; 1.18)

0.68 (0.39; 1.19)

0.66 (0.39; 1.12)

1.08 (0.46; 2.54)

0.65 (0.38; 1.10)

0.71 (0.36; 1.41)

0.71 (0.43; 1.16)

0.64 (0.37; 1.11)

T3

1.32 (0.89; 1.94)

1.30 (0.81; 2.09)

0.96 (0.65; 1.42)

0.91 (0.65; 1.28)

1.00 (0.67; 1.50)

1.02 (0.63; 1.65)

0.99 (0.67; 1.46)

1.04 (0.69; 1.58)

1.02 (0.61; 1.69)

1.08 (0.69; 1.69)

1.05 (0.71; 1.57)

1.71 (0.78; 3.76)

1.02 (0.67; 1.56)

1.13 (0.62; 2.05)

1.12 (0.75; 1.66)

1.02 (0.71; 1.46)

1.58 (0.90; 2.78)

T4

0.92 (0.51; 1.68)

0.91 (0.47; 1.76)

0.67 (0.36; 1.25)

0.64 (0.34; 1.19)

0.70 (0.38; 1.28)

0.71 (0.37; 1.38)

0.69 (0.38; 1.26)

0.73 (0.39; 1.36)

0.71 (0.36; 1.40)

0.75 (0.40; 1.43)

0.74 (0.40; 1.35)

1.20 (0.48; 2.96)

0.72 (0.39; 1.33)

0.79 (0.37; 1.67)

0.78 (0.43; 1.43)

0.71 (0.38; 1.34)

1.11 (0.52; 2.38)

0.70 (0.35; 1.39)

Ziprasidone

1.57 (1.36; 1.82)

1.56 (1.15; 2.11)

1.15 (0.93; 1.43)

1.09 (0.87; 1.37)

1.20 (1.01; 1.42)

1.22 (0.88; 1.68)

1.18 (1.03; 1.37)

1.25 (1.00; 1.56)

1.22 (0.85; 1.73)

1.29 (0.99; 1.68)

1.26 (1.07; 1.48)

2.05 (1.02; 4.11)

1.23 (1.00; 1.50)

1.35 (0.84; 2.17)

1.34 (1.14; 1.56)

1.22 (0.94; 1.58)

1.90 (1.16; 3.11)

1.20 (0.83; 1.72)

1.71 (0.96; 3.06)

Placebo