Table 2c.

League table for all cause discontinuation associated with studied pharmacological agents. For interpretation, larger than zero favors the column-defining treatment a cell. Values are RR with associated 95% confidence intervals.

Aripiprazole

0.43 (0.13; 1.49)

Brexpiprazole

1.07 (0.63; 1.82)

2.47 (0.70; 8.81)

Bupropion

0.83 (0.44; 1.55)

1.91 (0.51; 7.12)

0.77 (0.48; 1.23)

Buspirone

0.70 (0.40; 1.22)

1.62 (0.45; 5.83)

0.66 (0.35; 1.23)

0.85 (0.41; 1.74)

Cariprazine

1.43 (0.81; 2.52)

3.31 (0.91; 11.97)

1.34 (0.70; 2.54)

1.73 (0.84; 3.59)

2.04 (1.05; 3.96)

Lamotrigine

1.09 (0.69; 1.74)

2.53 (0.73; 8.76)

1.02 (0.59; 1.77)

1.32 (0.69; 2.53)

1.56 (0.88; 2.77)

0.76 (0.42; 1.38)

Lisdexamfetamine

0.92 (0.52; 1.61)

2.13 (0.59; 7.69)

0.86 (0.45; 1.63)

1.11 (0.54; 2.30)

1.31 (0.68; 2.54)

0.64 (0.34; 1.23)

0.84 (0.47; 1.51)

Lithium

1.00 (0.40; 2.51)

2.32 (0.53; 10.12)

0.94 (0.36; 2.46)

1.21 (0.43; 3.38)

1.43 (0.54; 3.80)

0.70 (0.26; 1.88)

0.92 (0.36; 2.32)

1.09 (0.41; 2.92)

Methylphenidate

0.29 (0.13; 0.65)

0.68 (0.17; 2.76)

0.27 (0.12; 0.64)

0.36 (0.14; 0.89)

0.42 (0.18; 1.00)

0.20 (0.09; 0.49)

0.27 (0.12; 0.61)

0.32 (0.13; 0.77)

0.29 (0.09; 0.91)

Mirtazapine

1.14 (0.63; 2.06)

2.64 (0.72; 9.65)

1.07 (0.55; 2.07)

1.38 (0.65; 2.92)

1.63 (0.82; 3.22)

0.80 (0.40; 1.60)

1.04 (0.57; 1.92)

1.24 (0.62; 2.48)

1.14 (0.42; 3.10)

3.89 (1.59; 9.52)

Modafinil

1.03 (0.66; 1.63)

2.39 (0.69; 8.27)

0.97 (0.56; 1.66)

1.25 (0.66; 2.38)

1.48 (0.84; 2.60)

0.72 (0.41; 1.29)

0.95 (0.59; 1.52)

1.13 (0.63; 2.00)

1.03 (0.41; 2.61)

3.53 (1.57; 7.93)

0.91 (0.50; 1.66)

Olanzapine

1.45 (0.63; 3.35)

3.35 (0.81; 13.97)

1.36 (0.56; 3.30)

1.76 (0.68; 4.56)

2.07 (0.84; 5.11)

1.01 (0.41; 2.53)

1.33 (0.57; 3.11)

1.58 (0.63; 3.92)

1.45 (0.45; 4.64)

4.95 (1.69; 14.48)

1.27 (0.50; 3.22)

1.40 (0.60; 3.26)

Pramipexole

1.06 (0.68; 1.66)

2.45 (0.71; 8.47)

0.99 (0.58; 1.70)

1.28 (0.68; 2.44)

1.51 (0.86; 2.66)

0.74 (0.42; 1.31)

0.97 (0.60; 1.56)

1.15 (0.74; 1.79)

1.06 (0.42; 2.67)

3.62 (1.61; 8.12)

0.93 (0.51; 1.70)

1.02 (0.64; 1.63)

0.73 (0.31; 1.70)

Quetiapine

0.95 (0.54; 1.69)

2.20 (0.61; 7.97)

0.89 (0.49; 1.61)

1.15 (0.62; 2.15)

1.36 (0.70; 2.64)

0.66 (0.34; 1.31)

0.87 (0.48; 1.57)

1.03 (0.53; 2.03)

0.95 (0.35; 2.56)

3.24 (1.34; 7.84)

0.83 (0.41; 1.68)

0.92 (0.51; 1.64)

0.66 (0.26; 1.64)

0.90 (0.50; 1.61)

Risperidone

2.73 (0.73; 10.25)

6.32 (1.09; 36.55)

2.56 (0.70; 9.36)

3.31 (0.93; 11.83)

3.90 (1.00; 15.26)

1.91 (0.49; 7.53)

2.50 (0.66; 9.46)

2.98 (0.76; 11.69)

2.73 (0.58; 12.85)

9.33 (2.12; 41.05)

2.40 (0.60; 9.54)

2.64 (0.70; 9.94)

1.89 (0.42; 8.47)

2.58 (0.69; 9.71)

2.88 (0.83; 9.98)

T4

0.06 (0.00; 1.05)

0.14 (0.01; 3.03)

0.06 (0.00; 0.99)

0.07 (0.00; 1.31)

0.09 (0.00; 1.52)

0.04 (0.00; 0.75)

0.05 (0.00; 0.96)

0.07 (0.00; 1.16)

0.06 (0.00; 1.17)

0.20 (0.01; 3.86)

0.05 (0.00; 0.94)

0.06 (0.00; 1.01)

0.04 (0.00; 0.79)

0.06 (0.00; 0.99)

0.06 (0.00; 1.13)

0.02 (0.00; 0.50)

Ziprasidone

1.21 (0.88; 1.65)

2.79 (0.85; 9.23)

1.13 (0.74; 1.73)

1.46 (0.84; 2.54)

1.72 (1.09; 2.73)

0.84 (0.52; 1.36)

1.11 (0.78; 1.56)

1.31 (0.82; 2.11)

1.21 (0.51; 2.86)

4.12 (1.97; 8.63)

1.06 (0.64; 1.76)

1.17 (0.84; 1.62)

0.83 (0.38; 1.81)

1.14 (0.82; 1.58)

1.27 (0.78; 2.06)

0.44 (0.12; 1.59)

20.12 (1.17; 344.58)

Placebo