Fig. 2. Both nuclear depletion and cytoplasmic accumulation of TDP-43 are relevant for neuronal dysfunction.

(A to D) Experimental (black) and theoretical (gray) time courses of MTT reduction (A and C) (n = 3) and mitochondrial superoxide production (B and D) (n = 3) in NSC-34 cells treated as in (A). The theoretical traces refer to nuclear depletion and cytoplasmic accumulation together (gray solid lines), only nuclear depletion (gray dashed lines), and only cytoplasmic accumulation (gray dotted lines). Experimental errors are SEMs. The degree of agreement [root mean square deviation (RMSD)] between experimental and theoretical analyses is also reported.