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. 2022 Jul 27;8(30):eabo4577. doi: 10.1126/sciadv.abo4577

Fig. 3. SMAD4-mediated transcriptional regulation of CD8+ T cell activation and cytotoxicity.

Fig. 3.

(A) KEGG pathway analysis of SMAD4-bound gene loci in activated CD8+ T cells. (B) Transcription factor motif analysis following SMAD4 ChIP-seq experiment on activated CD8+ T cells. (C) Venn diagram of SMAD4-regulated genes and SMAD4-bound genes. (D) SMAD4 peaks at the Cd247, Cd27, Cd8a, Gzmb, Prf1, and Fasl gene loci in activated CD8+ T cells (versus control input DNA).