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. Author manuscript; available in PMC: 2022 Jul 27.
Published in final edited form as: Oncology (Williston Park). 2022 Feb 8;36(2):97–106. doi: 10.46883.2022.25920946

FIGURE 1. Genomic Hallmarks of FL.

FIGURE 1.

BCL2 rearrangement with t(14;18) and mutations in epigenetic regulators are key molecular features in FL. BCL2 rearrangement is necessary, but not sufficient for lymphomagenesis. Founder mutations in FL often involve chromatin modifying proteins such as histone methyltransferases and acetyltransferases. Abnormal DNA methylation programming cooperates with somatic mutations to drive lymphomagenesis, while the acquisition of additional mutations contribute to disease progression and the risk of transformation to diffuse large B-cell lymphoma.

FL, follicular lymphoma.