Table 2.
Final formula for dorzolamide 2% eye drops solution.
| No. | Material | Amount | Function |
|---|---|---|---|
| 1 | Dorzolamide hydrochloride (corresponding to dorzolamide) | 22.30 mg (20.0 mg) | Active substance |
| 2 | Hydroxyethyl cellulose | 1.00 mg | Viscosity-increasing agent |
| 3 | Citric acid monohydrate | 4.00 mg | Buffering agent |
| 4 | Sodium hydroxide | 2.26 mg | Buffering agent |
| 5 | Mannitol | 20.00 mg | Tonicity agent |
| 6 | Benzalkonium chloride | 0.075 mg | Antimicrobial preservative |
| 7 | Purified water | 1.0 mL | Vehicle |
For the innovator formula, no details are published and available.