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. 2022 Jul 14;13:922760. doi: 10.3389/fmicb.2022.922760

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Copyright © 2022 Getahun, Ngiela, Makwatta, Ahuya, Simon, Kamau, Torto and Masiga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trypanocides treatment restored the metabolites back to normal. (A,B) Representaive GC-MS profiles showing key biomarker levels in trypanosome-infected (red) and after trypanocide treatment (purple). (C) The mean relative abundance of dihydro-β-ionone (D) dihydro-α-ionone at pre-infection, day 7 post-infection and after treatment. (E) The mean relative intensity of p-cresol and (F) 3-propylphenol at pre-infection, day 7 post-infection and after treatment. In (C–F), bars followed by different letters are statistically significant. Error bars represent standard error of the mean.