TABLE 2.
Association of Fluid Dose (≥ 30.0 vs < 30.0 mL/kg) With Outcomes: Before and After Propensity Score Weighted Analysis
| Outcomes | Fluid < 30 mL/kg (n = 6,074) | Fluid ≥ 30 mL/kg (n = 2,340) | Unweighted Analysis | p | PS-Weighted Analysis | p |
|---|---|---|---|---|---|---|
| OR or HR (95% CI) | OR or HR (95% CI) | |||||
| Primary outcome | ||||||
| In-hospital mortality | 442 (7.3%) | 198 (8.5%) | 1.18 (0.99–1.40) | 0.067 | 0.80 (0.66–0.96) | 0.020 |
| Secondary outcomes | ||||||
| Hospital length of stay after diagnosis, d | 4 (3–7) | 4 (3–7) | 0.98 (0.93–1.03)a | 0.37 | 1.02 (0.97–1.08) | 0.47 |
| Death within 30 d of diagnosis | 891 (14.7%) | 382 (16.3%) | 1.13 (1.00–1.29) | 0.058 | 0.81 (0.71–0.93) | 0.003 |
| ICU admission after diagnosis | 1,115 (22.1%), n = 5,046 | 681 (36.5%), n = 1,867 | 2.02 (1.80–2.27) | < 0.001 | 1.79 (1.60–2.01) | < 0.001 |
| Started dialysis after diagnosis | 36 (0.6%), n = 5,840 | 11 (0.5%), n = 2,270 | 0.79 (0.3–1.49) | 0.48 | 1.34 (0.73–2.38) | 0.33 |
| Mechanical ventilator use | 521 (8.6%) | 215 (9.2%) | 1.08 (0.91–1.27) | 0.41 | 0.79 (0.66–0.94) | 0.008 |
| Vasopressor use | 494 (8.1%) | 279 (11.9%) | 1.53 (1.31–1.78) | < 0.001 | 1.11 (0.94–1.30) | 0.22 |
HR = hazard ratio, OR = odds ratio, PS = propensity score.
aFor hospital length of stay after diagnosis, a HR > 1.00 represent better outcomes for patients who received 30 or more mL/kg of fluid compared with those who received < 30 mL/kg of fluid. For categorical outcomes, ORs > 1.00 represent worse outcomes for patients who received 30 or more mL/kg of fluid compared with those who received < 30 mL/kg of fluid.