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. 2022 Jul 20;607(7920):732–740. doi: 10.1038/s41586-022-04965-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Correlation between the number of LoF genes per sample and fraction of genome with runs of homozygosity. Shaded region represents 95% confidence interval. b, Number of homozygous loss-of-function (LoF) genes per sample. Count of homozygous genes annotated as high impact with frequency <1%. Results are presented for XBI, XAF, XSA excluding individuals self-identified as Pakistani, individuals self-identified as Pakistani from the XSA cohort and Others.