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. 2022 Jul 20;607(7920):732–740. doi: 10.1038/s41586-022-04965-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Coverage plot of RNA-sequenced reads from heart tissue from 169 heart tissue samples over the gene NMRK2. One individual is a carrier of a 754bp deletion depicted with gray rectangle that includes exon 6 of NMRK2. The RNA-coverage of the carrier (blue) is lower over exon 6 compared to median coverage of non-carriers (green). Shading marks the deleted region. b, Histogram of fraction of RNA-sequenced fragments skipping exon 6 in NMRK2 out of all fragments aligning from the donor site of exon 5 to either acceptor site of exon 6 or exon 7. The median fraction fragments skipping for wild-type individuals is 0.035 and 0.57 for the carrier of the 754bp deletion.