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. 2022 Jul 20;607(7920):732–740. doi: 10.1038/s41586-022-04965-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, The number of WGS samples analysed for phenotypes in our study. b, UMAP plot generated from the first 40 principal components of all UKB participants, coloured by self-reported ethnicity: blue shades for ethnic labels under the white category (XBI), red shades for Black individuals (XAF) and green shades for South Asian individuals (XSA); for the full colour legend, see Supplementary Fig. 17. c, Joint frequency spectrum of variants on chromosome 20 between all pairs of populations. d–f, Characteristics of the XBI cohort across Great Britain and Ireland are shown: the number of singletons carried by individuals in the XBI cohort as a function of place of birth (d); the mean number of third-degree relatives by administrative division (e); and the location of UKB assessment centres and estimated fraction of the surrounding population recruited to the UKB (f). Differences in singleton counts and the number of third-degree relatives are probably a result of denser sampling of individuals living near UKB assessment centres. Fig. 3d–f by K.H.S.M.