Table 3.
Enrichment of cCREs from ENCODE among low DR regions defined at the 1% and 5% percentiles
| cCREsa | Genome (%) | Enrichment (OR (95% CI)) | |
|---|---|---|---|
| DR 1% percentile | DR 5% percentile | ||
| pELS, CTCF-bound | 0.53 | 6.35 (6.04–6.68) | 3.49 (3.37–3.61) |
| PLS, CTCF-bound | 0.15 | 6.37 (6–6.75) | 3.34 (3.19–3.49) |
| PLS | 0.05 | 2.77 (2.53–3.03) | 1.9 (1.79–2.03) |
| pELS | 0.53 | 2.49 (2.39–2.63) | 1.96 (1.9–2.02) |
| DNase H3K4me3, CTCF-bound | 0.07 | 1.92 (1.67–2.19) | 1.48 (1.38–1.59) |
| dELS, CTCF-bound | 1.86 | 1.65 (1.58–1.71) | 1.53 (1.5–1.57) |
| dELS | 4.11 | 1.17 (1.13–1.2) | 1.27 (1.25–1.3) |
| DNase H3K4me3 | 0.15 | 1.15 (1.04–1.27) | 1.03 (0.974–1.08) |
| CTCF only | 0.47 | 0.878 (0.83–0.925) | 0.96 (0.933–0.987) |
The percentage of the genome covered by candidate cis-regulatory elements (cCREs) are indicated for each type of cCRE.
CTCF, CCCTC-binding factor; dELS, distal enhancer-like sequence; OR, odds ratio; pELS, proximal enhancer-like sequence; PLS, promoter-like sequence.
aExons of protein-coding genes found in overlap with cCRE regions were removed.