Figure 1.

Longitudinal antibody dynamics among patients with blood culture-confirmed enteric fever

Longitudinal antibody dynamics were fit to ELISA-measured antibody responses using Bayesian hierarchical models. (A) The light coloured lines are the observed individual antibody concentrations; each line indicates one patient. The dark solid line indicates the median and dotted lines indicate 95% credible intervals for the model-fitted antibody decay concentrations. The white horizontal line marks the median baseline antibody response for each antigen isotype. (B) The median model-fitted antibody trajectories for each age stratum. (C) The median model-fitted antibody trajectories for patients with Salmonella Typhi to Salmonella Paratyphi A. Ages are restricted to 5–15 years old because patients with S Paratyphi A were older than patients with S Typhi. HlyE=hemolysin E. LPS=lipopolysaccharide.