Table 3.

Tumor type prediction by sarcoma methylation classifier^*

Diagnosis	Age/Sex	Site	Fusion	Calibrated score	Matching methylation class
AFH	21/M	groin	EWSR1-CREB1	0.33	angiomatoid fibrous histiocytoma
AFH	16/M	scalp	EWSR1-CREB1	0.75	angiomatoid fibrous histiocytoma
AFH	79/F	knee	EWSR1-ATF1	< 0.3	no matching methylation class
AFH	22/F	inguinal	EWSR1-CREB1	< 0.3	no matching methylation class
AFH	34/M	foot	EWSR1-ATF1	< 0.3	no matching methylation class
AFH	17/M	axilla	EWSR1-CREB1	0.74	squamous cell carcinoma (cutaneous)
CCS	20/F	heel	EWSR1-ATF1	0.99	clear cell sarcoma of soft parts
CCS	30/M	knee	EWSR1-ATF1	0.99	clear cell sarcoma of soft parts
CCS	24/M	arm	EWSR1-ATF1	0.99	clear cell sarcoma of soft parts
CCS	46/F	hip	EWSR1-ATF1	0.99	clear cell sarcoma of soft parts
GI CCS	42/F	small bowel	EWSR1-CREB1	0.56	angiomatoid fibrous histiocytoma
GI CCS	47/F	small bowel	EWSR1-CREB1	0.65	clear cell sarcoma of soft parts
GI CCS	57/M	stomach	EWSR1-CREB1	0.96	clear cell sarcoma of soft parts
GI CCS	42/F	small bowel	EWSR1-CREB1	0.51	neurofibroma (plexiform)
GI CCS	19/F	mesentery	EWSR1-ATF1	< 0.3	no matching methylation class
GI CCS	76/F	colon	EWSR1-CREB1	< 0.3	no matching methylation class
GI CCS	18/F	small bowel	EWSR1-ATF1	< 0.3	no matching methylation class
GI CCS	25/M	stomach	EWSR1-CREM	0.68	sclerosing epithelioid fibrosarcoma
ME	20/F	peri-rectal	EWSR1-CREM	< 0.3	no matching methylation class
Meso	26/F	peritoneal	FUS-ATF1	< 0.3	no matching methylation class
Meso	34/F	pleura	EWSR1-ATF1	< 0.3	no matching methylation class
Meso	79/F	mediastinum	EWSR1-ATF1	< 0.3	no matching methylation class

^*Percentage matched: AFH 33.3%, CCS 100%, GICCS/ME/meso (methylation class doesn’t exist in the classifier)

Abbreviations—AFH: angiomatoid fibrous histiocytoma; CCS: clear cell sarcoma; GICCS: clear cell sarcoma-like tumor of gastrointestinal tract; ME: malignant epithelioid neoplasm with predilection for mesothelial-lined cavities; Meso: mesothelioma.