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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: J Invest Dermatol. 2022 Feb 7;142(8):2140–2148.e1. doi: 10.1016/j.jid.2022.01.022

Figure 3. Immunofluorescent staining of H2AX and PAR shows co-localization of DNA damage response, PAR production, and mineral deposits in the lesional skin of patients with PXE.

Figure 3.

Paraffin sections of skin biopsies from three healthy controls and three PXE patients were analyzed. Bar = 400 μm. Please note the positivity of the green fluorescent signals of H2AX (a) and PAR (b) in association with mineral deposits (red fluorescence), as shown as yellow in the overlay. Cell nuclei were stained with DAPI.