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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Cyst Fibros. 2022 Mar 2;21(4):637–643. doi: 10.1016/j.jcf.2022.02.011

Figure 2: Effect of chronic VX-770 treatment in the presence of VX-661 and VX-445 on F508del-CFTR function.

Figure 2:

F508del/F508del HNE cells were chronically (24 h) treated with either DMSO (Ctrl) or the combination of VX-661 (3 μM) and VX-445 (3 μM) (red), and chronically co-treated with either DMSO (0 μM) or increasing concentrations of VX-770 (0.1–6.4 μM) (A) Representative traces of activation and inhibition of CFTR by Fsk/IBMX and CFTRinh-172, respectively. (B–C) Changes in ISC in response to Fsk/IBMX (B) or CFTRinh-172 (C). Data are presented as mean ± standard error. Groups with different letters are significantly different (P < 0.05) from each other (n = 3–4 unique donors; one-way ANOVA; Tukey’s post hoc).