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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: J Cyst Fibros. 2022 Mar 2;21(4):637–643. doi: 10.1016/j.jcf.2022.02.011

Figure 3: Increased constitutive F508del-CFTR activity in the presence of chronic VX-661, VX-445, and VX-770 explains apparent decrease in Fsk/IBMX responsiveness.

Figure 3:

(A) Values for constitutive CFTR activity were calculated as the difference between ISC before Fsk/IBMX addition and after CFTRnh-172 addition in the presence of amiloride. (B) Constitutive CFTR activity calculated from data presented in Figs. 1 and 2. Data are presented as mean ± standard error. Groups with different letters are significantly different (P < 0.05) from each other (n = 3–4 unique donors; two-way ANOVA; Tukey’s post hoc). (C) Relationship between Fsk/IBMX responsive ISC and constitutive CFTR activity data from experiment presented in Fig. 2.