The overall effect (95% CrIs) of toxic metals (Hg, Pb, Cd) on child OWO is defined as the difference in the response when all the exposures are fixed at a specific quantile (ranging from 0.10 to 0.90), as compared to when all the exposures are fixed at their median value. Maternal age, BMI, race/ethnicity, marital status, education level, parity, breastfeeding type, smoking status, fish intake, child’s sex, low birthweight, and preterm status were included as the covariates. (A) Red group shows the overall effect on OWO risk among children whose mothers have OWO and have Se levels in T1, while the blue group shows the overall effect among children of mothers with OWO and with Se levels in T2–T3. (B) Red group shows the overall effect on OWO risk among children whose mothers have OWO and have folate levels in T1, while the blue group shows the overall effect among children of mothers with OWO and with folate levels in T2–T3. Note: Although the blue and red groups in (A) and (B) have the same quantiles (from 0.10 to 0.90), the blue group was slightly right-shifted to make the two sets of CrIs more clearly visible.