Table 2.

Reactions with trimethylsilyldiazomethane.

Catalyst (1 mol%), entries 1 and 3: CH₂Cl₂ (6.5 mL), substrate (2.5 mmol, 5.0 equiv), add Me₃SiCHN₂ (0.5 mmol, 1.0 equiv, in hexanes + 6.5 mL CH₂Cl₂) in 6 hours at RT. Rest of entries: substrate used as solvent (10 mL, 128–246 equiv). Yields are isolated yields. [a] Isolated as a mixture of isomers. [b] Yield determined by ¹H NMR spectroscopy with an internal standard.