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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2022 Jun 10;61(31):e202200334. doi: 10.1002/anie.202200334

Table 5.

Comparison of catalysts 2 and 4.

graphic file with name nihms-1808739-t0006.jpg
Catalyst 1 h 2 h 3 h 6 h 12 h 24 h 48 h
2 45 % 66 % 85 % 92 % 93 % 95 % 95 %
4 14 % 24 % 34 % 44 % 54 % 64 % 83 %
[a]

Catalyst (1 mol%), CH2Cl2 (12.5 mL) + cyclohexane (10 mL), add ethyl diazoacetate (1.0 mmol, 1.0 equiv) in CH2Cl2 (1.0 mL) in 1–48 hours at RT. Yields determined by 1H-NMR analysis with an internal standard.