Table 4.

Cox Proportional Hazards Regression Model for 8th Edition AJCC cT Subcategories, Age at Presentation, Treatment Modality, and Heritable Trait Associated with Metastatic Mortality in 1841 Patients with Retinoblastoma

Variable	Patients, No. (N = 1841)	Reference	HR (95% CI)	P Value
cT2b	814	cT2a	1.6 (0.5–5.4)	0.424
cT3b	166	cT2a	3.5 (0.9–14.2)	0.082
cT3c	389	cT2a	4.9 (1.4–16.3)	0.011
cT3d	203	cT2a	14.0 (4.2–46.1)	<0.001
cT3e	51	cT2a	19.6 (5.4–71.0)	<0.001
Systemic chemotherapy followed by secondary enucleation	315	Primary enucleation	3.3 (2.0–5.4)	<0.001
Systemic chemotherapy and eye salvage	398	Primary enucleation	4.9 (2.9–8.3)	<0.001
Age (mos)
8.0–17.0	437	<8.0	0.7 (0.3–1.6)	0.443
17.0–29.0	502	<8.0	2.7 (1.4–5.2)	0.002
>29.0	519	<8.0	2.8 (1.5–5.6)	0.002
H1	636	H0	1.4 (0.9–2.2)	0.116

AJCC = American Joint Committee on Cancer; c = clinical; CI = confidence interval; HR = hazard ratio; T = tumor.