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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Kidney Int. 2022 Apr 22;102(2):293–306. doi: 10.1016/j.kint.2022.02.038

Figure 1: TEC-specific RTN1A overexpression accelerated renal function decline in STZ-induced diabetic mice.

Figure 1:

(A) Kidney-to-body weight (K/BW) ratio at 29 weeks post-diabetes induction in control and Pax8-RTN1A mice. (B) Total 24-hour urinary albumin excretion at 29 weeks post-diabetes induction. (C) Blood urea nitrogen (BUN) levels at 29 weeks post-diabetes induction. (D) Representative images of periodic acid-Schiff (PAS)-stained kidneys at 100x (top) and 400x magnifications (scale bars: 20μm, top panel, and 10μm, bottom panel). (E) Quantification of average tubular injury score, mesangial matrix fraction (%) and the glomerular area is shown per mouse (n=5 mice per group).*p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001 between indicated groups by two-way ANOVA with Tukey's post hoc analysis or nonparametric Mann-Whitney test (for tubular injury scores).