Table 2 |.
Mean (SD) P-tau 181 and 217 levels by group and percent with abnormal values by group using different methods for selecting cutpoints
| Characteristic | CU A− N=589 |
CU A+ N=303 |
MCI or DEM A− N=48 |
MCI or DEM A+ N=111 |
Total N=1051 |
P-value |
|---|---|---|---|---|---|---|
| Plasma biomarker levels | ||||||
| Plasma Lilly P-tau181 | 1.02 (0.37) | 1.65 (0.83) | 1.16 (0.41) | 2.64 (3.49) | 1.38 (1.35) | <0.001a |
| Plasma Lilly P-tau217 | 0.13 (0.06) | 0.27 (0.16) | 0.15 (0.06) | 0.46 (0.61) | 0.21 (0.24) | <0.001a |
| Without stroke/MI/CKD | ||||||
| P-tau 181 >=1.57 | 42 (7.1%) | 135 (44.6%) | 9 (18.8%) | 78 (70.3%) | 264 (25.1%) | <0.001b |
| P-tau 217 >=0.25 | 19 (3.2%) | 134 (44.2%) | 4 (8.3%) | 77 (69.4%) | 234 (22.3%) | <0.001c |
| With stroke/MI/CKD | ||||||
| P-tau 181 >=1.75 | 22 (3.7%) | 103 (34.0%) | 4 (8.3%) | 69 (62.2%) | 198 (18.8%) | <0.001c |
| P-tau 217 >=0.26 | 10 (1.7%) | 120 (39.6%) | 2 (4.2%) | 73 (65.8%) | 205 (19.5%) | <0.001c |
Numbers indicate N (%) unless otherwise noted.
a
Anova F-test.
b
Chi-square.
c
Fisher exact. All p-values are two-sided and are not adjusted for multiple comparisons.
CKD, chronic kidney disease; CU, cognitively unimpaired; DEM, dementia; MI, myocardial infarction; SD, standard deviation.