Table 2.
Summary of cytokine measurements in CSF.
| Cytokine | Timepoint | CSF Median [IQR] (pg/mL) |
Adjusted-p value Wilcoxon Signed-Rank Test between T1 and T2 | Average fold change |
|---|---|---|---|---|
| IL-1β |
T1 T2 |
0.14 [0.14–0.15] 0.60 [0.36–0.84] |
< 0.01 | 5.4 |
| IL-2 |
T1 T2 |
0.20 [0.20–0.23] 0.30 [0.21–0.81] |
< 0.05 | 4.6 |
| IL-4 |
T1 T2 |
0.02 [0.01–0.03] 0.03 [0.01–0.08] |
ns | 4.5 |
| IL-6 |
T1 T2 |
0.98 [0.39–1.28] 15.91 [9.73–62.57] |
< 0.01 | 63.3 |
| IL-8 |
T1 T2 |
26.85 [9.35–42.32] 919.23 [333.42–1366.63] |
< 0.01 | 31.0 |
| IL-10 |
T1 T2 |
0.30 [0.19–0.43] 0.85 [0.37–1.00] |
< 0.05 | 4.5 |
| IL-12p70 |
T1 T2 |
0.09 [0.08–0.17] 0.11 [0.08–0.12] |
ns | 2.8 |
| IL-13 |
T1 T2 |
1.14 [0.55–1.86] 2.78 [1.67–12.75] |
< 0.01 | 5.2 |
| IFN-γ |
T1 T2 |
0.605 [0.54–0.67] 0.605 [0.54–0.63] |
ns | 2.6 |
| TNF-α |
T1 T2 |
0.52 [0.32–0.96] 0.99 [0.51–2.10] |
ns | 3.9 |
Cytokine levels in cerebrospinal fluid (CSF) before surgery (T1) and the day after surgery (T2), ns = non-significant.