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. 2022 Jul 27;13(7):651. doi: 10.1038/s41419-022-05111-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic illustration of the proposed model. Normoxic CSCs get more access to the blood vessels than hypoxic CSCs. Hypoxic cell-secreted lactate in the TME could be ingested by normoxic CSCs to promote their OXPHOS and thus enhance their metastatic capacity.