Fig. 1. Gene-level associations with waist-to-hip ratio adjusted for BMI.

Gene-based burden analysis of WHRadjBMI in 362,679 European ancestry individuals. Association testing was performed using a generalized linear model adjusting for the first 30 principal components of genetic ancestry. The best variant set per gene is shown and significant genes are labeled (P ≤ 1.05 × 10⁻⁶; Bonferroni correcting for the number of genes and variant masks tested). The dashed line indicates the threshold for statistical significance.