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. 2022 Jul 27;13:4319. doi: 10.1038/s41467-022-31757-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — For significant genes, we plotted the estimated log odds of disease risk as a function of the estimated effect in standard deviations (SD) on WHRadjBMI calculated in 362,679 European ancestry participants. Effects are shown for INHBE pLOF and, for the other genes, the most significant variant set per gene. a Effect on WHRadjBMI (in SD) versus the log odds of CHD (b) Effect on WHRadjBMI (in SD) versus the log odds of T2D. Grey bars represent the 95% confidence interval. The blue dotted line represents the estimated effect on disease predicted by a MR study of WHRadjBMI¹.