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. 2022 Jul 27;12:12821. doi: 10.1038/s41598-022-15050-8

Table 1.

Anti-proliferative activity of pyrazolines 9 BC MDA-MB-231 and T-47D cancer cell lines, as well as towards breast MCF-10A normal cells.

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Com X R R1 R2 IC50 (µM)a
MDA-MB-231 T-47D MCF-10A
9a F H H H 19.84 ± 1.08 NAb NDc
9b F H H OH 12.24 ± 0.67 18.61 ± 0.87 NDc
9c F H H N(CH3)2 2.54 ± 0.138 8.45 ± 0.27 47.03 ± 3.52
9d F OMe H H 45.02 ± 2.45 NAb NDc
9e F H H OMe 14.13 ± 0.77 12.37 ± 0.33 NDc
9f. F OH OMe H 3.40 ± 0.185 27.1 ± 1.08 42.60 ± 2.81
9g F H OH OMe 0.62 ± 0.03 3.14 ± 0.11 31.74 ± 3.10
9h F H OMe OH 5.82 ± 0.317 11.42 ± 0.67 79.45 ± 5.27
9i Cl H H H 24.68 ± 1.35 NAb NDc
9j Cl H H OH 6.24 ± 0.34 35.10 ± 2.04 65.37 ± 5.04
9k Cl H H N(CH3)2 1.14 ± 0.06 4.92 ± 0.28 58.51 ± 4.36
9l Cl OMe H H 58.01 ± 3.16 NAb NDc
9m Cl H H OMe 18.95 ± 1.03 27.63 ± 1.24 NDc
9n Cl OH OMe H 35.15 ± 1.916 67.29 ± 2.51 NDc
9o Cl H OH OMe 10.81 ± 0.59 7.36 ± 0.30 NDc
9p Cl H OMe OH 6.55 ± 0.357 19.47 ± 0.92 83.62 ± 6.74
Doxorubicin 3.67 ± 0.20 2.73 ± 0.09 NDc
Erolitinib 2.88 ± 0.17 3.61 ± 0.24

aIC50 value is the mean ± S.D. of 3 separate experiments.

bNA: Derivatives with IC50 more than 100 mM.

cND: Not determined.