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. 2022 Jul 27;12:12767. doi: 10.1038/s41598-022-16285-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Suppressive role of DJ-1 on osteoclastogenesis under IL-17A stimulation. CD14⁺ monocytes from HC (n = 6) were cultured with IL-17A (50 ng/mL) + M-CSF (25 ng/mL) without or with DJ-1 (10, 50, 100 ng/mL). (A) Number of TRAP⁺ multinucleated cells. (B) Gene expression of TRAP, OC-sTAMP, ATP6v0d2, NFATc1, and CTSK osteoclasts measured using RT-qPCR. Data were normalized to ACTB expression and are reported in relative expression units. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bar = 200 μm.