Table 1.
Characteristics of similarities and differences in pyroptosis, apoptosis and necroptosis.
| Characteristics | Pyroptosis | Apoptosis | Necroptosis |
|---|---|---|---|
| Programmed cell death | + | + | + |
| Membrane rupture | + | − | + |
| Selective channels | − | − | + |
| Nonselective pore formation | + | − | − |
| Membrane blebbing | + | + | − |
| Osmotic lysis | + | − | + |
| DNA damage | + | + | + |
| Organelle swelling | − | − | + |
| Chromatin condensation | + | + | − |
| Caspase-1/4/5/11 activation | + | − | − |
| Caspase-2/7/10 activation | − | + | − |
| Caspase-3/6/8/9 activation | + | + | − |
| EtBr staining | + | − | + |
| PI staining | + | − | + |
| 7-AAD staining | + | − | + |
| Annexin V staining | + | + | + |
| TUNEL staining | + | + | + |
| Cell swelling | + | − | + |
| Cell shrink | − | + | − |
| Intact nucleus | + | − | + |
| Pyroptotic bodies | + | − | − |
| Apoptotic bodies | − | + | − |
| Necroptotic bodies | − | − | + |
| Inflammation | + | − | + |
| PARP cleavage | + | + | − |
| Gasdermin cleavage | + | − | − |
| ROCK1 cleavage | − | + | − |
| Phosphorylation of MLKL/RIP3 | − | − | + |