Table 3.
Summary of regents induce pyroptosis in cancers.
| Cancer types | Regents | Experimental subjects | Target | References |
|---|---|---|---|---|
| NPC | BIX-01294 + cis-platinum | 1. CNE-2Z cell; 2. xenograft animal model | Caspase-3/GSDME | [130] |
| Taxol | 1. HNE-2 and 5–8 F cells; 2. xenograft animal model | Caspase-1/GSDMD | [115] | |
| Lobaplatin | 1. CNE-1, S26, HONE-1, SUNE-1 and CNE-2 cells | Caspase-3/GSDME | [116] | |
| 2. xenograft animal model | ||||
| Tanshinone IIA | 1. HK1 cells | Caspase-1/GSDMD | [142] | |
| GC | 5-FU | 1. SGC-7901 and MKN-45 cells | Caspase-3/GSDME | [68] |
| BIX-01294 + Cisplatin | 1. SGC-7901 cells; 2. xenograft animal model | Caspase-3/GSDME | [143] | |
| ESCC | Alpinumisoflavone | 1. KYSE510 and KYSE30 cell; 2. xenograft animal model | Caspase-3/GSDME | [118] |
| BI2536 + Cisplatin | 1. KYSE150 and KYSE510 cells; 2. Xenograft animal model | Caspase-3/GSDME | [128] | |
| Metformin | 1. KYSE510 and KYSE140 cells; 2. xenograft animal model | GSDMD | [86] | |
| HCC | Miltirone | 1. HepG2 or Hepa1-6 cells; 2. HCC syngeneic model | Caspase-3/GSDME | [144] |
| Berberine | 1. HepG2 cell; 2. xenograft mouse model | Caspase-1 | [53] | |
| Alpinumisoflavone | 1. SMMC 7721 and Huh7 cells; 2. Xenograft HCC model | NLRP3 inflammasome | [119] | |
| Curcumin | 1. HepG2 cell | GSDME | [145] | |
| E2 | 1. HepG2 cell | NLRP3 /Caspase-1 | [58] | |
| Euxanthone | 1. Hep3B and SMMC 7721 cells; 2. Xenograft HCC model | Caspase-2 | [120] | |
| Sorafenib | 1. Macrophages cell; 2. orthotopic HCC mouse models | Caspase -1 | [146] | |
| CRC | AA and ATO | 1. SW620 and LOVO cells | Caspase -1 | [129] |
| GW4064 plus oxaliplatin | 1. HT-29 and SW620 cells; 2. Xenograft mouse model | Caspase-3/GSDME | [75] | |
| Lobaplatin | 1. HT-29 and HCT116 cells; 2. Xenograft mouse model | Caspase-3/GSDME | [51] | |
| Simvastatin | 1. H1299 and A549 cells; 2. Xenograft mouse model | NLRP3/Caspase-1 | [122] | |
| NSCLC | PPVI | 1. A549 and H1299 cells; 2. Xenograft mouse model | NLRP3/Caspase-1/GSDMD | [121] |
| Cisplatin | 1. A549 cell | Caspase-3/GSDME | [117] | |
| Paclitaxel | 1. A549 cell | Caspase-3/GSDME | [117] | |
| L50377 | 1. A549 and NCI–H460 cells | GSDME | [123] | |
| Resibufogenin | 1. A549 and H520 cells; 2. Xenograft mouse model | NLRP3 /Caspase-1 | [124] | |
| Huaier extract | 1. H520 and H358 cells; 2. Xenograft mouse model | NLRP3/Caspase-1 | [125] | |
| Simvastatin | 1. A549 and H1299 cells; 2. Xenograft mouse model | NLRP3/Caspase-1 | [122] | |
| BC | Omega-3 fatty acids | 1. MDA-MB-231 cell | Caspase-1/GSDMD | [147] |
| Dihydroartemisinin | 1. MCF7 and MDA-MB-231 cells; 2. xenograft mouse model | AIM2/Caspase-3/GSDME | [148] | |
| Nobiletin | 1. MCF7 and BT-549 cells; 2. xenograft mouse model | NLRP3/Caspase-1/GSDMD | [149] | |
| Tetraarsenic hexoxide | 1. EO771, 4T1, Hs578T, and MDA-MB-231 cells; 2. Orthotopic mouse models | Caspase-3/GSDME | [150] | |
| OSCC | Anthocyanin | 1. Hacat, Tca8113 and SCC15 cells | NLRP3/CASPASE-1/GSDMD | [151] |
| CC | Tanshinone IIA | 1. HeLa cell | GSDMD | [152] |
| PCB29-pQ | 1. HeLa cell | Caspase-1/GSDMD | [153] |
NPC nasopharyngeal carcinoma, GC gastric cancer, ESCC oesophageal squamous cell carcinoma, HCC hepatocellular carcinoma, CRC colorectal cancer, NSCLC non-small cell lung cancer, BC breast cancer, OSCC oral squamous cell carcinoma, CC cervical cancer.