Table 1.
Information on used studies and consortia
| Exposure or outcome | Unit | Participants included in analysis | Adjustments | Identified SNPs | Variance explained | F-statistic | OR at 80% power | PubMed ID |
|---|---|---|---|---|---|---|---|---|
| Body mass index | SD (~ 4.8 kg/m2) | 806 834 European-descent individuals | Age, sex, and genetic 1–5 principal components | 312 | 7.7% | 286 | ≤ 0.95 or ≥ 1.05 | 25,673,413 |
| Waist circumference | SD | 224 459 European-descent individuals | Age and study-specific covariates | 47 | 1.2% | 86 | ≤ 0.89 or ≥ 1.11 | 25,673,412 |
| Waist circumference adjusted for BMI | SD | 224 459 European-descent individuals | Age, body mass index and study-specific covariates | 70 | 1.5% | 72 | ≤ 0.90 or ≥ 1.10 | 25,673,412 |
| Type 2 diabetes | One-unit in log-transformed odds ratio | 228 499 type 2 diabetes cases and 1 178 783 non-cases of multi-ancestries | Age, sex, and the first ten genetic principal components | 558 | 19.0% | 140 | ≤ 0.97 or ≥ 1.03 | 32,541,925 |
| Smoking initiation | SD in prevalence of smoking initiation | 1 232 091 European-descent individuals | Age, sex, and the first ten genetic principal components | 378 | 2.3% | 21 | ≤ 0.92 or ≥ 1.08 | 30,643,251 |
| Alcohol drinking | SD increase of log-transformed alcoholic drinks/week | 941 280 European-descent individuals | Age, sex, and the first ten genetic principal components | 99 | 0.7% | 24 | ≤ 0.86 or ≥ 1.15 | 30,643,251 |
| Coffee consumption | 50% change | 375 833 European-descent individuals | Age, sex, body mass index, total energy, proportion of typical food intake and 20 genetic principal components | 14 | 0.5% | 119 | ≤ 0.84 or ≥ 1.18 | 31,046,077 |
| Caffeine consumption | 80 mg (close to caffeine from one cup of coffee) | 9876 European-descent individuals | Age, sex, study-site, fasting status, family structure, genetic principal components, and smoking status | 2 | 1.3% | 2190 | ≤ 0.89 or ≥ 1.11 | 27,702,941 |
| GERD | Log-transformed odds ratio | 71 522 GERD cases and 261 079 controls of European descent | Recruitment age, genetic sex, the first ten principal components, and cryptic relatedness | – | – | – | – | 31,527,586 |
GERD Gastroesophageal reflux disease; ID Identifier; OR Odds ratio; SD Standard deviation; SNPs Single-nucleotide polymorphism.