Table 4.
Mediation of genetically predicted diabetes, systolic blood pressure, and lipids in the Mendelian randomization association between body mass index and nonalcoholic fatty liver disease
| Model | Effect on NAFLD | Mediation effect | ||
|---|---|---|---|---|
| OR | 95% CI | Mediation | 95% CI | |
| BMI without adjustment | 1.33 | 1.23, 1.43 | – | – |
| BMI adjusted for type 2 diabetes | 1.15 | 1.04, 1.27 | 51.4% | 13.4–89.3% |
| BMI adjusted for systolic blood pressure | 1.33 | 1.23, 1.43 | 0.00% | − 39.8–37.8% |
| BMI adjusted for high− density lipoprotein cholesterol | 1.20 | 1.09, 1.32 | 35.5% | − 2.5–73.5% |
| BMI adjusted for triglycerides | 1.23 | 1.12, 1.34 | 27.7% | − 9.7–65.0% |
BMI Body Mass Index, CI confidence interval, NAFLD nonalcoholic fatty liver disease, OR odds ratio