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. 2022 Jul 27;12:12798. doi: 10.1038/s41598-022-16499-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RiSC was higher in the severe-IVH group compared to other IVH groups after accounting for the effect of birthweight (Right panel; Tukey post-hoc test showed P = 0.04 in severe vs mild groups and P = 0.06 in severe vs no-IVH groups). Each point was based on one day of measurement. The plot on the left shows the original distribution before adjusting for body weight. The right panel shows the RiSC comparison after adjusting for the birthweight. Both the original RiSC and adjusted RiSC were marginally different in ELGA infants who were diagnosed with IVH within 72 h of life compared to controls (P = 0.07 and 0.07, respectively). (Red dot = diagnosed with IVH within 72 h of life; Blue open circle = no IVH within 72 h of life.)