Table 3.
Cross-classification of predicted risk of breast cancer among the whole study population, according to the percentiles of each PRS.
| Percentiles of PRS-A (%) | Percentiles of PRS-B | ||||||
|---|---|---|---|---|---|---|---|
| < 1% | 1–20% | 20–40% | 40–60% | 60–80% | 80–99% | ≥ 99% | |
| < 1 | 345 (20.1, 20.1, 0.2) | 1140 (66.5, 3.5, 0.7) | 176 (10.3, 0.5, 0.1) | 44 (2.6, 0.1, 0.0) | 9 (0.5, 0.0, 0.0) | 1 (0.1, 0.0, 0.0) | 0 (0.0, 0.0, 0.0) |
| 1–20 | 1117 (3.4, 65.1, 0.7) | 15,409 (47.3, 47.3, 9.0) | 8818 (27.1, 25.7, 5.1) | 4696 (14.4, 13.7, 2.7) | 2052 (6.3, 6.0, 1.2) | 490 (1.5, 1.5, 0.3) | 1 (0.0, 0.1, 0.0) |
| 20–40 | 198 (0.6, 11.5, 0.1) | 8788 (25.6, 27.0, 5.1) | 9989 (29.1, 29.1, 5.8) | 8053 (23.5, 23.5, 4.7) | 5210 (15.2, 15.2, 3.0) | 2051 (6.0, 6.3, 1.2) | 9 (0.0, 0.5, 0.0) |
| 40–60 | 43 (0.1, 2.5, 0.0) | 4648 (13.6, 14.3, 2.7) | 7998 (23.3, 23.3, 4.7) | 8908 (26.0, 26.0, 5.2) | 8050 (23.5, 23.5, 4.7) | 4607 (13.4, 14.1, 2.7) | 44 (0.1, 2.6, 0.0) |
| 60–80 | 11 (0.0, 0.6, 0.0) | 2098 (6.1, 6.4, 1.2) | 5296 (15.4, 15.4, 3.1) | 7988 (23.3, 23.3, 4.7) | 10,047 (29.3, 29.3, 5.9) | 8688 (25.3, 26.7, 5.1) | 170 (0.5, 9.9, 0.1) |
| 80–99 | 1 (0.0, 0.1, 0.0) | 497 (1.5, 1.5, 0.3) | 2006 (6.2, 5.8, 1.2) | 4574 (14.0, 13.3, 2.7) | 8736 (26.8, 25.5, 5.1) | 15,674 (48.1, 48.1, 9.1) | 1095 (3.4, 63.8, 0.6) |
| ≥ 99 | 0 (0.0, 0.0, 0.0) | 3 (0.2, 0.0, 0.0) | 15 (0.9, 0.0, 0.0) | 35 (2.0, 0.1, 0.0) | 194 (11.3, 0.6, 0.1) | 1072 (62.5, 3.3, 0.6) | 396 (23.1, 23.1, 0.2) |
Number of participants are shown as n (col%, row%, cell%). Higher percentiles of PRS indicate increased risk of breast cancer; “≥ 99%” percentile corresponds to the top 1% risk.