Table 1.

Comparison of human/humanized models of infection

	Cerebral Organoids	Transgenic Animal	Primary Cell Culture	Organotypic Slice
Cost of Generation	+	+++	+	++
Cost of Maintenance	+	+++	+	+
Difficulty of Generation	++	+++	+	+
Difficulty of Maintenance	+	++	+	+
Cell Diversity	+++	+++	+	+++
Experimental Timeframe	++	+++	+	+
Time to Maturity	+	++/+++(*)	+	+
Scalability	+++	+	+++	++
Proximity to Humans	+++	++	+	++

⁺minimal

⁺⁺average

⁺⁺⁺high

^(*)depending on the infection subtype