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. 2022 Jul 14;13:918212. doi: 10.3389/fendo.2022.918212

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Copyright © 2022 Chen, Ding, Wu, Qiu, Li, Ye and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of master regulators in the 20-29 age group vs. the 30-39 age group. (A) Top 20 transcription factors with differential protein activity enrichment (B–D) Significantly activated transcription factors in the 30-39 age group for the diagnosis of ovarian senescence in the reproductive years (VAV1, RUNX3, IRF5). (E–G) Significantly activated transcription factors in the 20-29 age group for the diagnosis of ovarian senescence in the reproductive age group (KDM1A, PRDM5, ZNF726). Act: TF activation; Exp: TF expression.