Table 1.

Functional enrichment of the core regulatory module of the protein-protein interaction network.

Network	Annotation
MCODE_RED	R-HSA-2262752|Cellular responses to stress;R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence;R-HSA-8953897|Cellular responses to stimuli.
MCODE_GREEN	GO:0019646|aerobic electron transport chain;GO:0042775|mitochondrial ATP synthesis coupled electron transport;GO:0042773|ATP synthesis coupled electron transport.
MCODE_BLUE	GO:0030185|nitric oxide transport;R-HSA-1247673|Erythrocytes take up oxygen and release carbon dioxide;R-HSA-2168880|Scavenging of heme from plasma.

In Figure 4D , MCODE_RED refers to the signal pathway enriched in the core genes of the PPI regulatory network in the red module; MCODE_GREEN refers to the signal pathway enriched in the core genes of the PPI regulatory network in the green module; MCODE_BLUE refers to the signal enriched in the core genes of the PPI regulatory network in the blue module communication.